Super-hydrodynamic limit in interacting particle systems

This paper is a follow-up of the work initiated in [3], where it has been investigated the hydrodynamic limit of symmetric independent random walkers with birth at the origin and death at the rightmost occupied site. Here we obtain two further results: first we characterize the stationary states on the hydrodynamic time scale and show that they are given by a family of linear macroscopic profiles whose parameters are determined by the current reservoirs and the system mass. Then we prove the existence of a super-hyrdrodynamic time scale, beyond the hydrodynamic one. On this larger time scale the system mass fluctuates and correspondingly the macroscopic profile of the system randomly moves within the family of linear profiles, with the randomness of a Brownian motion.Comment: 22 page

Finding Person Relations in Image Data of the Internet Archive

The multimedia content in the World Wide Web is rapidly growing and contains valuable information for many applications in different domains. For this reason, the Internet Archive initiative has been gathering billions of time-versioned web pages since the mid-nineties. However, the huge amount of data is rarely labeled with appropriate metadata and automatic approaches are required to enable semantic search. Normally, the textual content of the Internet Archive is used to extract entities and their possible relations across domains such as politics and entertainment, whereas image and video content is usually neglected. In this paper, we introduce a system for person recognition in image content of web news stored in the Internet Archive. Thus, the system complements entity recognition in text and allows researchers and analysts to track media coverage and relations of persons more precisely. Based on a deep learning face recognition approach, we suggest a system that automatically detects persons of interest and gathers sample material, which is subsequently used to identify them in the image data of the Internet Archive. We evaluate the performance of the face recognition system on an appropriate standard benchmark dataset and demonstrate the feasibility of the approach with two use cases

Tumor cellular and microenvironmental cues controlling invadopodia formation

During the metastatic progression, invading cells might achieve degradation and subsequent invasion into the extracellular matrix (ECM) and the underlying vasculature using invadopodia, F-actin-based and force-supporting protrusive membrane structures, operating focalized proteolysis. Their formation is a dynamic process requiring the combined and synergistic activity of ECM-modifying proteins with cellular receptors, and the interplay with factors from the tumor microenvironment (TME). Significant advances have been made in understanding how invadopodia are assembled and how they progress in degradative protrusions, as well as their disassembly, and the cooperation between cellular signals and ECM conditions governing invadopodia formation and activity, holding promise to translation into the identification of molecular targets for therapeutic interventions. These findings have revealed the existence of biochemical and mechanical interactions not only between the actin cores of invadopodia and specific intracellular structures, including the cell nucleus, the microtubular network, and vesicular trafficking players, but also with elements of the TME, such as stromal cells, ECM components, mechanical forces, and metabolic conditions. These interactions reflect the complexity and intricate regulation of invadopodia and suggest that many aspects of their formation and function remain to be determined. In this review, we will provide a brief description of invadopodia and tackle the most recent findings on their regulation by cellular signaling as well as by inputs from the TME. The identification and interplay between these inputs will offer a deeper mechanistic understanding of cell invasion during the metastatic process and will help the development of more effective therapeutic strategies

Development of Lumped Element Kinetic Inductance Detectors for the W-Band

We are developing a Lumped Element Kinetic Inductance Detector (LEKID) array able to operate in the W-band (75-110 GHz) in order to perform ground-based Cosmic Microwave Background (CMB) and mm-wave astronomical observations. The W-band is close to optimal in terms of contamination of the CMB from Galactic synchrotron, free-free, and thermal interstellar dust. In this band, the atmosphere has very good transparency, allowing interesting ground-based observations with large (>30 m) telescopes, achieving high angular resolution (<0.4 arcmin). In this work we describe the startup measurements devoted to the optimization of a W-band camera/spectrometer prototype for large aperture telescopes like the 64 m SRT (Sardinia Radio Telescope). In the process of selecting the best superconducting film for the LEKID, we characterized a 40 nm thick Aluminum 2-pixel array. We measured the minimum frequency able to break CPs (i.e. $h\nu=2\Delta\left(T_{c}\right)=3.5k_{B}T_{c}$) obtaining $\nu=95.5$ GHz, that corresponds to a critical temperature of 1.31 K. This is not suitable to cover the entire W-band. For an 80 nm layer the minimum frequency decreases to 93.2 GHz, which corresponds to a critical temperature of 1.28 K; this value is still suboptimal for W-band operation. Further increase of the Al film thickness results in bad performance of the detector. We have thus considered a Titanium-Aluminum bi-layer (10 nm thick Ti + 25 nm thick Al, already tested in other laboratories), for which we measured a critical temperature of 820 mK and a cut-on frequency of 65 GHz: so this solution allows operation in the entire W-band.Comment: 16th International Workshop on Low Temperature Detectors, Grenoble 20-24 July 2015, Journal of Low Temperature Physics, Accepte

Hubungan Tingkat Kecemasan Dengan Mekanisme Koping Pada Pasien Gagal Jantung Kongestif Diruangan Cvbc (Cardio Vaskuler Brain Centre) Lantai III Di Rsup. Prof. Dr. R. D. Kandou Manado

: Congestive heart failure is often difficult to maintain oxygenation and so they then shortness of breath and anxiety.Anxiety is a reaction to the disease as perceived as a threat, discomfort. Coping mechanism is a method to adapt to the changes that. Occur. The purpose of the study was to patients with congestive heart failure at CVBC III floor RSUP.PROF.DR.R.D.Kandou Manado.The design of this study using cross-sectional. Sample of 33 people, with purposive sampling method.Data were collected by interview using a questionnaire.The results of the study found a 12,1% rate of mild anxiety, medium anxiety 48,5% severe anxiety 39,4% and adaptive coping mechanism 63,6% maladaptive coping 36,4%. The results of hypothesis testing with Fisher's exact test shows that the value of p=0,003, p is less than α(0,05).Conclusion that there is a relationship anxiety levels with coping mechanisms in patients with congestive heart faiure.advicefor hospitals anxiety levels had a significant relationship with coping mechanisms by because it is for hospitals to be more emphasizing on counseling so that patients can control anxiety and constructive coping mechanisms

Natural compounds for pediatric cancer treatment

There is a tremendous need in clinics to impair cancer progression through noninvasive therapeutic approaches. The use of natural compounds to achieve this is of importance to improve the quality of life of young patients during their treatments. This review will address the "status of the art" related to the potential of natural compounds that are undergoing investigation in combination with standard therapeutic protocols in preclinical and clinical studies and their importance for pediatric cancer treatment. The early studies of drug discovery of these natural compounds discussed here include the main targets, the cellular signaling pathways involved, and the potential modes of action. We also focus on some promising natural compounds that have shown excellent results in vitro and in vivo: Chebulagic acid, Apigenin, Norcantharidin, Saffron/Crocin, Parthenolide, Longikaurin E, Lupeol, Spongistatin 1, and Deoxy-variolin B. Additionally, we introduce the effects of several compounds from nutraceutical and functional foods, to underline their potential use as adjuvant therapies to improve therapeutic benefits. For this purpose, we have selected several compounds: Agaritine, Ganoderma and GL6 peptide, Diallyl trisulfide and Ajoene from garlic, Epigallocatechin gallate from green tea, Curcumin, Resveratrol, and Quercetin

Lattice Dynamics in the Half-Space, II. Energy Transport Equation

We consider the lattice dynamics in the half-space. The initial data are random according to a probability measure which enforces slow spatial variation on the linear scale $\varepsilon^{-1}$. We establish two time regimes. For times of order $\varepsilon^{-\gamma}$, $0<\gamma<1$, locally the measure converges to a Gaussian measure which is time stationary with a covariance inherited from the initial measure (non-Gaussian, in general). For times of order $\varepsilon^{-1}$, this covariance changes in time and is governed by a semiclassical transport equation.Comment: 35 page

Hubungan Dukungan Keluarga Dengan Keputusan Inisiasi Hemodialisis Pada Penderita Penyakit Ginjal Kronik Di Ruang Dahlia Rsup Prof. Dr. R. D. Kandou Manado

:Initiation hemodialysis is start of the process hemodialysis as renal replacement therapy in patients with chronic kidney disease. Family support is attitude , actions and acceptance of family to patients where family support can influence the decision of initiation hemodialysis.Purpose of this study was to analyze the relationship of the family support with the decision of initiation hemodialysis on patient chronic kidneys disease in Dahlia Room RSUP.Prof.Dr.R.D.Kandou Manado. Research method is used descriptive analytic with cross sectional design. Sampling technique in research is purposive sampling with 41 samples. Data collected by using a questionnaire.the data processed by using SPSS with chi - square test, with a significance level of 95% ( =0,05).Results showed that the number of respondents with good family support there were 63.4% respondents who did not delay the initiation of hemodialysis decision 61% of respondents, while respondents with less family support 36.6% of the respondents and delaying decisions initiation of hemodialysis 31,7% of respondents and p value = <0.001.Conclusion there is a meaningful relationship between family support with the initiation of hemodialysis decision. Recomendation for further is expected to be a reference for more research on family support with decision of initiation hemodialysis

Interactions between sympathetic nervous system and endogenous endothelin in patients with essential hypertension

Experimental evidence indicates that endothelin 1 stimulates the sympathetic nervous system by activation of the subtype A receptor. The aim of the present study was to assess whether this mechanism is active in humans and to investigate its potential role in the pathogenesis of essential hypertension. In 15 hypertensive patients and 12 normotensive subjects, blood pressure, heart rate, and muscle sympathetic nerve activity were evaluated during intravenous 20-minute infusion of BQ123 (0.1 mg/kg per hour), an endothelin A receptor antagonist, and sodium nitroprusside (SNP; 0.4 μg/kg per minute). In hypertensive patients, blood pressure was reduced similarly by BQ123 and SNP. In contrast, the increase in muscle sympathetic nerve activity induced by BQ123 (from 52.0±4.9 to 56.8±5.5 bursts per 100 heartbeats; P<0.05 versus baseline) was significantly lower (P<0.05) than that induced by SNP (from 50.6±4.9 to 61.1±5.1 bursts per 100 heartbeats; P<0.05 versus baseline). In normotensive subjects, SNP reduced blood pressure and increased muscle sympathetic activity, whereas BQ123 was ineffective. Thus, in a subgroup (n=9) of normotensive subjects, we administered BQ123 at a higher dose (0.2 mg/kg per hour), representing an equidepressor dose of SNP, inducing a blunted increase in sympathetic activity (from 44.1±2.4 to 50.1±6.4 bursts per 100 heartbeats; P<0.05 versus baseline). Finally, administration of a different vasodilator (papaverine, 0.5 mg/kg per hour) exerted results superimposable to SNP. Endogenous endothelin 1 appears to have a sympathoexcitatory effect both in normotensive and hypertensive subjects through endothelin A receptors, contributing to basal sympathetic vasomotor tone. Moreover, essential hypertension shows an increased susceptibility to the sympathoexcitatory effect of endogenous endothelin 1